Endocrine Abstracts

Introduction: Severe insulin resistance syndromes are rare syndromes characterized by clinical features like: acanthosis nigricans, ovarian hyper androgenism in post pubertal females: hirsuitism, oligomenorrhea and infertility.Major causes of severe insulin resistance are: i) genetic defects in insulin receptor like type A syndrome, or ii) autoimmune like antibodies to insulin receptor like in type B syndrome or antibodies to insulin itself, iii) congeni...